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Two primary controllers are peptide hormones produced by the brains hypothalamus, growth hormone releasing hormone (GHRH) and somatostatin, which act in a dynamic equilibrium to regulate circulating GH levels: when the hypothalamus detects reduced blood levels of GH, it releases GHRH which stimulates specialized cells in the pituitary to synthesize and secrete GH

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A landmark randomized trial also demonstrated a 37% average reduction in hepatic (liver) fat among participants with HIV-associated nonalcoholic fatty liver disease, which has opened up a whole new avenue of research interest